Nisa Services

	The Fertility Center at Nisa Premier Hospital Abuja is well equipped and has experience in providing comprehensive fertility treatment to our patients
	Pre-Implantation Genetic Diagnosis (for Sickle cell anaemia and Aneuploidy )
	Sickle Cell Anemia Disease and PGD
	Sickle cell anemia is an autosomal recessive genetic disorder caused by a defect in the HBB gene, which codes for hemoglobin. Hemoglobin is the main substance in red blood cells and responsible for carrying oxygen from the air in the lungs to all parts of the body.
	In most cases both parents are carriers of the abnormal gene, having one normal gene and one abnormal gene. The presence of two abnormal genes is needed for sickle cell anemia. If each parent carries one sickle hemoglobin gene and one normal gene, each child has a 1 in 4 (25 %) chance of inheriting two defective genes and having sickle cell anemia, 1 in 4 (25 %) of having two normal genes and not having the disease, and a 50% chance of inheriting one normal and one abnormal gene and being an unaffected carrier like the parents. Some couples opt for prenatal diagnosis during pregnancy to determine whether a pregnancy is affected.
	An alternative to prenatal testing for sickle cell anemia is now available using in vitro fertilization (IVF) with PGD to identify an unaffected embryo. In vitro fertilization (IVF) is the process of combining eggs and sperm to form embryos in the laboratory. IVF is often used to help couples with infertility have a child. Preimplantation genetic diagnosis is a procedure to analyze the genetic make-up of embryos formed through IVF for determination of disease status. Couples at risk for having a child with sickle cell anemia can use PGD to test for this disease. Based on this analysis, embryos that are not affected with sickle cell anemia can be selected for transfer to the uterus to establish a pregnancy.
	Aneuploidy Screening (Pre-Implantation Genetic Screening - PGS)
	It should be noted that genetic disorders could be due to either a single gene disorder (disorder resulting from mutation affecting individual genes on a chromosome) or abnormal number or structure of chromosome. In single gene disorders, such as sickle cell anemia, the actual genes of the sampled embryo can be examined for the presence of the condition.
	Other genetic disorders, such as Duchenne's muscular dystrophy, or hemophilia, affect only males (sex linked diseases). In these cases, the cell is examined to determine the sex of the embryo and only female embryos are replaced. In cases of recurrent chromosomal abnormalities such as Down's syndrome and recurrent miscarriages caused by parental translocations, the number and character of several chromosomes can be determined.
	Ovulatory induction and cycle monitoring
	Intra-uterine insemination (IUI) (Partner or Donor insemination)
	In Vitro fertilisation (IVF)
	The gametes (eggs and sperm) are mixed together in a dish and sperm penetrate the eggs to fertilise then naturally. This procedure is used for patient with normal sperm parameters.
	Intra-cytoplasmic Sperm injection (ICSI)
	For patient with low sperm count/high abnormal/MAR positive sample. A single sperm is taken up in a fine glass needle and is injected directly into an egg.
	Intra morphological sperm injection (IMSI) (suitable for patient with repetitive IVF/ICSI failed cycle)
	One aspect of male fertility which can be measured and which relates to fertility is the level of abnormalities present in the sperm. Such abnormalities result in poorer quality sperm which in turn may reduce the possibility of fertilisation of an egg and have also been shown to effect the health of an embryo from which a pregnancy can occur.
	Many sperm abnormalities can be identified by the embryologist using a normal microscope with magnification x400-600. This is used when ICSI treatment is performed .However, by looking at sperm using much higher magnifications (up to x6000) coupled with a digital imaging system, it has recently become possible to identify structures within the sperm head known as vacuoles which cannot be seen with a normal microscope.
	Assisted hatching
	Ovum donation
	Egg Sharing
	Ovum Recipient
	Blastocyst transfer
	The transfer of day 5-6 embryos. Blastocyst transfers are carried out when we can be confident of achieving a high quality transfer. We have a simple criteria to select those patients suitable for blastocyst transfer. Our Services Our Medical Services Assisted hatching Blastocyst transfer Pre-conception care Ante-natal care Fetal surveillance Ovum Recipient Ultrasound scan General Surgery Cardiotocography
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	Day 1	Day 2		Day 3	Day 4		Day 5
	*Embryo development at different stages
	Egg /Embryo/blastocyst freezing by vitrification
	Sperm Freezing
	Counselling